Extensions
- OME-TIFF - Open Microscopy Environment TIFF
 A specification of how to embed OME-XML metadata within a TIFF or BigTIFF image file.
Tools
- Bio-Formats
 Bio-Formats reads proprietary microscopy image data and metadata, and converts them to OME-TIFF, a combination of TIFF and OME-XML.
- Fiji
 Fiji is an image processing package that supports the OME data model for images
- OMERO
 Repository software for organising, viewing, analysing and sharing biological microscopy images. It supports proprietary file formats but normalises to OME-TIFF/OME-XML.
Metadata standards
- OME-XML - Open Microscopy Environment XML
 A metadata standard and data file format for biological light microscopy data.